One of the most frustrating diagnoses a couple can receive when trying to conceive is unexplained infertility. It means that despite thorough testing, no specific cause of infertility can be found in either partner.
This condition affects around 10–20% of infertile couples, and although it may sound reassuring that “nothing is wrong,” it can leave couples feeling confused and helpless.
What Is Unexplained Infertility?
Unexplained infertility is typically diagnosed when:
- The woman is ovulating regularly
- Her fallopian tubes are open and healthy (no adhesions, fibroids, or endometriosis)
- The uterus appears normal
- The man has a normal sperm count, motility, and morphology
In other words, all standard fertility tests come back normal, yet pregnancy still isn’t occurring.
Why Does It Happen?
Even with advanced medical tools, some aspects of fertility remain beyond what current testing can detect. Possible (but undiagnosed) contributors to unexplained infertility may include:
- Subtle hormonal imbalances
- Egg quality issues not seen in standard testing
- Sperm DNA fragmentation
- Immune system factors affecting implantation
- Timing or quality of intercourse
What Are the Next Steps?
Being diagnosed with unexplained infertility doesn’t mean there are no options—it just means more personalized approaches may be needed.
Common treatment strategies include:
- Lifestyle changes – Improving diet, exercise, and reducing stress or toxins
- Ovulation induction with timed intercourse – Even if ovulation is regular, medications like Clomid may help boost chances
- Intrauterine insemination (IUI) – Placing sperm directly into the uterus to increase the likelihood of fertilization
- In vitro fertilization (IVF) – Often considered after failed IUI cycles or if the couple is older
- Advanced testing – Genetic screening, sperm DNA testing, or laparoscopy to look for hidden issues
Final Thoughts
An unexplained infertility diagnosis may feel like you’re stuck without answers—but you’re not without hope. Many couples with this diagnosis go on to conceive with the right treatment and support.
Early consultation with a fertility specialist is key to creating a plan that works for your unique situation.